Major Depressive Disorder: Treatment-Resistant Depression and Augmentation of Other Medication Classes

Major Depressive Disorder: Treatment-Resistant Depression and Augmentation of Other Medication Classes

Identification: MSNJ1912
Issue: July-August 2019
Volume: Vol. 28/No. 4
Credits (Post Test and/or Evaluation Required)
Available until 08/31/2021
  • 1.30 - CH
  • 0.60 - Rx

Non-member: $20.00


Major depressive disorder (MDD) is one of the most common reasons patients present for medical care worldwide. Nurses should be aware of the occurrence of and pharmacological treatment for MTD and treatment-resistant depression (TRD). Holistic nursing plays a pivotal role in caring for patients with TRD.

Learning Outcome:

After completing this learning activity, the learner will be able to understand the importance of holistically assessing the person with MDD or TRD to initiate appropriate treatment.

Learning Engagement Activity:

1. Identify 3 risk factors that predispose people to Treatment-Related Depression.
2. Describe why using the algorithm of optimization, switching, and augmentation tends to be a good treatment approach.

Contact hours available until 8/31/2021.

Requirements for Successful Completion:
Complete the learning activity in its entirety and complete the online CNE evaluation.

Authors Conflict of Interest Disclosure:

The author(s), editor, editorial board, content reviewers, and education director reported no actual or potential conflict of interest in relation to this continuing nursing education article.

Commercial Support and Sponsorship:
No commercial support or sponsorship declared.

Accreditation Information:
This educational activity is jointly provided by Anthony J. Jannetti, Inc. and the Academy of Medical-Surgical Nurses (AMSN).

Anthony J. Jannetti, Inc. is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation.

Anthony J. Jannetti, Inc. is a provider approved by the California Board of Registered Nursing, provider number CEP 5387. Licensees in the state of California must retain this certificate for four years after the CNE activity is completed.

This article was reviewed and formatted for contact hour credit by Michelle Boyd, MSN, RN, AMSN Education Director.


Credits Available

Expired On: Aug 31, 2021

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Jagir Kaur
8/13/19 3:32 am

very knowledgeable article

Frank Haecker
8/18/19 3:08 am

Very good educational activity.

Elizabeth Dickey
9/11/19 2:27 pm

Great article filled with insightful information.

Sandra LaPointe
10/6/19 5:30 pm

The article was applicable to holistic approaches to nurses as well as understanding that those with anxiety and mood disorders can be treatment resistant.

Mokulongo Manzembe
10/10/19 10:13 pm

Picked up wrong choices on the evaluation. Great article about TRD and liked the pharmacology portion.

Kirsten McLaughlin
11/22/19 5:20 pm

Very informative article

Michelle Rudolph
12/16/19 4:34 am

very interesting article about depression

Jonah Lagat
4/18/20 11:00 pm

Very informative article about psych

Patrice Robinson
6/12/20 7:39 am

Very knowledgeable article. We need more of these types of articles.

Anal Rathod
9/2/20 6:07 pm

Great article. Agree with that pharmacological approach with TRD and other triggering factors need to be address simultaneously.

Brenda Williams
9/7/20 2:05 pm

Need more articles like this and addressing other factors and diving deeper into Mental Health.

Wendy Tsaninos
4/6/21 12:24 am

Excellent explanation about how drugs interact and are selected for tx

Anita Arguello
4/22/21 12:03 am

I did not know that TRD existed. Informative and simply stated.

Alketa Stephens
5/2/21 3:09 pm

very knowledgeable article about augmentation and other medication classes. I learned a lot.